CYP1A1 and CYP2E1 polymorphism frequencies in a large Brazilian population
نویسندگان
چکیده
منابع مشابه
Polymorphism of the CYP1A1*2A gene and susceptibility to lung cancer in a Brazilian population.
OBJECTIVE To estimate and compare the frequency of CYP1A1*2A gene polymorphisms in a Brazilian population and determine the possible contribution of these genetic variations to lung cancer risk. METHODS The study population included 200 patients with lung cancer, and the control group consisted of 264 blood donors. Genomic DNA was obtained from peripheral blood samples. The PCR-RFLP method wa...
متن کاملGenotype and allelic frequencies of CYP2E1*5B polymorphism in the southwest population of Iran
Background: Cytochrome P450 2E1 (CYP2E1) is a main enzyme which plays a major role in activating and detoxifying many xenobiotics, carcinogens and drugs. Available studies suggest that CYP2E1 single nucleotide polymorphisms (SNPs) are involved in the risk of developing certain cancers after exposure to carcinogens. The purpose of the present study was to assess genotype and allele frequencies o...
متن کاملCYP2E1*5B, CYP2E1*6, CYP2E1*7B, CYP2E1*2, and CYP2E1*3 allele frequencies in iranian populations.
BACKGROUND CYP2E1 encodes an enzyme which is mainly involved in bioactivation of potential carcinogens such as N-nitrosamines. Polymorphisms in the gene have been reported to be associated with cancer. The aim of this study was to evaluate genotype distributions and allele frequencies of five CYP2E1 polymorphisms in Iran. MATERIALS AND METHOD Two hundred healthy individuals of an Iranian popu...
متن کاملAssociation of CYP1A1 and CYP2E1 gene polymorphisms with prostate cancer in a Lebanese population
*Corresponding Author E-mail: [email protected] Tel.:+961 3 48 69 15; Fax +961 5 46 07 96 The present study investigates the association of the genetic polymorphisms of cytochromes P450 (CYP) 1A1 and 2E1 with prostate cancer (PCa), which is among the most common cancers in Lebanon and many countries. Prostate cancer is a multifactor disease where genetic polymorphisms of genes involved...
متن کاملCYP1A1, CYP2E1 and EPHX1 polymorphisms in sporadic colorectal neoplasms
AIM To investigate the contribution of polymorphisms in the CYP1A1, CYP2E1 and EPHX1 genes on sporadic colorectal cancer (SCRC) risk. METHODS Six hundred forty-one individuals (227 patients with SCRC and 400 controls) were enrolled in the study. The variables analyzed were age, gender, tobacco and alcohol consumption, and clinical and histopathological tumor parameters. The CYP1A1*2A, CYP1A1*...
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ژورنال
عنوان ژورنال: Genetics and Molecular Biology
سال: 2007
ISSN: 1415-4757
DOI: 10.1590/s1415-47572007000100001